NeuroHope Therapeutics, Inc. - Patents and Grants
PATENTS
US 10,232,050 B1
Multi-functional particle and methods of using the same
Inventor: Jeoung Soo Lee
US 11,633,355 B2
Multi-functional particle and methods of using the same
Inventor: Jeoung Soo Lee
Multi-functional particle and methods of using the same
Inventor: Jeoung Soo Lee
US 11,633,355 B2
Multi-functional particle and methods of using the same
Inventor: Jeoung Soo Lee
Pending Grant
NIH STTR Phase I
“Rolipram Loaded Nanotherapeutics for Spinal Cord Injury”
Agency: NIH/NINDS
“Rolipram Loaded Nanotherapeutics for Spinal Cord Injury”
Agency: NIH/NINDS
Current Grants
DoD, SBIR
“Dexamethasone nanotherapeutics for traumatic brain injury”
Phase I grant
Awarded February 2025
$250,000
iRED (IDeA Regional Entrepreneurship Development Program 2nd cohort)
"XLerator Network Selects 8 Life Science Startups Across Southeast" for NIH-Funded Entrepreneurship Program
Awarded August 2024
$25,000
SCRA (South Carolina Research Authority)
Academic Startup Grant
Agency: South Carolina Research Authority
Awarded June 2023
$25,000
SCIRF-IIR
“Evaluation of toxicity and therapeutic treatment window of rolipram-loaded PgP for SCI”
Agency: South Carolina - Spinal Cord Injury Research Fund
Role: Principal Investigator
Period: 7/15/2023-7/14/2025
NIH R01
“Regulation of SCI-induced pain by macrophages and exercise”
Agency: NIH/NINDS
Role: Co-Principal Investigator (PI: Megan Detloff, Drexel University)
Period: 11/15/2023-11/14/2028
Pilot Grant
“Macrophage-targeted nanotherapeutic to reduce SCI Pain”
Agency: Craig H Neilson Foundation
Role: Co-Principal Investigator (PI: Megan Detloff, Drexel University)
Period: 8/15/2023-8/14/2025
NIH R01 NS111037-01
"Neuron-specific Nanotherapeutics for Spinal Cord Injury Repair"
Agency: NIH/NINDS
Role: Principal Investigator
Period: 2/1/2019-1/31/2025
$ 1,311,562
NIH 1R21 1R21NS114723-01A1
“Preclinical Evaluation of Combination Therapy of Rolipram and Minocycline for Arresting Secondary Injury Cascade After Traumatic Brain Injury”
Agency: NIH/NINDS
Role: Co-Principal Investigator (PI: Dr. Murray, Louisiana Tech University)
Period: 9/1/2020-8/31/2024
NIH 1R21 1R21NS118224-01
“Microglial RGS10 as a therapeutic target for Lewy body diseases”
Agency: NIH/NINDS
Role: Co-Principal Investigator (PI: Dr. Jae-Kyung Lee, UGA)
Period: 9/1/2020-8/31/2024
$148,625 sub-award
BX000347-11
“Cerebral arteriole structure/function in diabetic ischemic brain injury”
Agency: Veterans Administration
Role: Co-Principal Investigator (PI: Dr. Adviye Ergul, MUSC)
Period: 1/15/2022-1/14/2026
Pilot project
“Establishment of feline SCI model and new MR imaging capabilities for assessment of therapeutic efficacy”
Agency: SC-BioCRAFT / NIH
Role: Principal Investigator
Period: 8/15/2022-6/30/2024
“Dexamethasone nanotherapeutics for traumatic brain injury”
Phase I grant
Awarded February 2025
$250,000
iRED (IDeA Regional Entrepreneurship Development Program 2nd cohort)
"XLerator Network Selects 8 Life Science Startups Across Southeast" for NIH-Funded Entrepreneurship Program
Awarded August 2024
$25,000
SCRA (South Carolina Research Authority)
Academic Startup Grant
Agency: South Carolina Research Authority
Awarded June 2023
$25,000
SCIRF-IIR
“Evaluation of toxicity and therapeutic treatment window of rolipram-loaded PgP for SCI”
Agency: South Carolina - Spinal Cord Injury Research Fund
Role: Principal Investigator
Period: 7/15/2023-7/14/2025
NIH R01
“Regulation of SCI-induced pain by macrophages and exercise”
Agency: NIH/NINDS
Role: Co-Principal Investigator (PI: Megan Detloff, Drexel University)
Period: 11/15/2023-11/14/2028
Pilot Grant
“Macrophage-targeted nanotherapeutic to reduce SCI Pain”
Agency: Craig H Neilson Foundation
Role: Co-Principal Investigator (PI: Megan Detloff, Drexel University)
Period: 8/15/2023-8/14/2025
NIH R01 NS111037-01
"Neuron-specific Nanotherapeutics for Spinal Cord Injury Repair"
Agency: NIH/NINDS
Role: Principal Investigator
Period: 2/1/2019-1/31/2025
$ 1,311,562
NIH 1R21 1R21NS114723-01A1
“Preclinical Evaluation of Combination Therapy of Rolipram and Minocycline for Arresting Secondary Injury Cascade After Traumatic Brain Injury”
Agency: NIH/NINDS
Role: Co-Principal Investigator (PI: Dr. Murray, Louisiana Tech University)
Period: 9/1/2020-8/31/2024
NIH 1R21 1R21NS118224-01
“Microglial RGS10 as a therapeutic target for Lewy body diseases”
Agency: NIH/NINDS
Role: Co-Principal Investigator (PI: Dr. Jae-Kyung Lee, UGA)
Period: 9/1/2020-8/31/2024
$148,625 sub-award
BX000347-11
“Cerebral arteriole structure/function in diabetic ischemic brain injury”
Agency: Veterans Administration
Role: Co-Principal Investigator (PI: Dr. Adviye Ergul, MUSC)
Period: 1/15/2022-1/14/2026
Pilot project
“Establishment of feline SCI model and new MR imaging capabilities for assessment of therapeutic efficacy”
Agency: SC-BioCRAFT / NIH
Role: Principal Investigator
Period: 8/15/2022-6/30/2024
Completed Grant Funding
5 R01 GM120487-01
“Characterization of various multifunctional nucleic acid nanoparticles and understanding their immunotoxicity”
Agency: NIH/NCI R01
Role: Co- Principal Investigator (PI: Dr. Afonin, PI, UNC)
Period: 9/15/2018-9/14/2021
$ 394,999 sub-award
SC-SCIRF 2017 B-01
“Multifunctional nanotherapeutics for SCI repair”
Agency: South Carolina Spinal Cord Injury Research Fund
Role: Principal Investigator
Period: 4/1/2018-9/30/2020
$69,000
P20GM103444
“Target-specific Polymeric Micelle/ siRNA Complex Nanotherapeutics for Traumatic Brain Injury”
Agency: NIH/ NIGMS COBRE Phase II,
Role: Target Project Principal Investigator (PI: Vyavahare)
Period: 7/1/2014-6/30/2019
$514,000 sub-award
SC-SCIRF
“Neuron-specific nanotherapeutics for axonal regeneration after spinal cord injury”
Agency: (South Carolina Spinal Cord Injury Research Fund)
Role: Principal Investigator
Period: 1/2014-12/2016
$39,000
SCBioMat Target Project
“Target-specific Polymeric Micelle/ siRNA Complex Nanotherapeutics for Traumatic Brain Injury”
Agency: NIH/ COBRE
Role: Principal Investigator
Period: 7/2013-6/2014
$100,000
SCBioMat Pilot Project
“Target-specific Polymeric Micelle/ siRNA Complex Nanotherapeutics for Traumatic Brain Injury”
Agency: NIH/ COBRE,
Role: Principal Investigator
Period: 8/2012-6/2013
$50,000
“Characterization of various multifunctional nucleic acid nanoparticles and understanding their immunotoxicity”
Agency: NIH/NCI R01
Role: Co- Principal Investigator (PI: Dr. Afonin, PI, UNC)
Period: 9/15/2018-9/14/2021
$ 394,999 sub-award
SC-SCIRF 2017 B-01
“Multifunctional nanotherapeutics for SCI repair”
Agency: South Carolina Spinal Cord Injury Research Fund
Role: Principal Investigator
Period: 4/1/2018-9/30/2020
$69,000
P20GM103444
“Target-specific Polymeric Micelle/ siRNA Complex Nanotherapeutics for Traumatic Brain Injury”
Agency: NIH/ NIGMS COBRE Phase II,
Role: Target Project Principal Investigator (PI: Vyavahare)
Period: 7/1/2014-6/30/2019
$514,000 sub-award
SC-SCIRF
“Neuron-specific nanotherapeutics for axonal regeneration after spinal cord injury”
Agency: (South Carolina Spinal Cord Injury Research Fund)
Role: Principal Investigator
Period: 1/2014-12/2016
$39,000
SCBioMat Target Project
“Target-specific Polymeric Micelle/ siRNA Complex Nanotherapeutics for Traumatic Brain Injury”
Agency: NIH/ COBRE
Role: Principal Investigator
Period: 7/2013-6/2014
$100,000
SCBioMat Pilot Project
“Target-specific Polymeric Micelle/ siRNA Complex Nanotherapeutics for Traumatic Brain Injury”
Agency: NIH/ COBRE,
Role: Principal Investigator
Period: 8/2012-6/2013
$50,000